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1.
Ciênc. Saúde Colet. (Impr.) ; 24(6): 2325-2340, jun. 2019. tab
Artigo em Inglês | LILACS | ID: biblio-1011809

RESUMO

Abstract This study sought to investigate the association of exposure to organochlorine (OC) and non-persistent pesticides with hematological parameters in an agricultural population in Southern Brazil. A cross-sectional study was conducted with a random sample of 275 farm workers and their families in Farroupilha-RS. A questionnaire was used to collect information on sociodemographic and lifestyle factors, duration, frequency and type of pesticide used, among others. Blood samples were collected and analyzed for serum concentration of 24 OC pesticides and hematological parameters. Associations were explored through linear regression, controlling for confounders. Lifetime use of chemical classes other than organophosphates and dithiocarbamates were associated with decreased number of lymphocytes, while subjects sampled in the high pesticide use season showed higher number of erythrocytes and hemoglobin level. Detectable serum levels of many OC pesticides were associated with lower counts of white blood cells, particularly eosinophils. Although mostly null associations were observed between pesticide use and hematological parameters, findings may suggest that OC pesticides could lead to hematological alterations among agricultural workers.


Resumo O objetivo deste estudo foi investigar a associação entre a exposição a organoclorados (OC) e agrotóxicos não persistentes e os parâmetros hematológicos em uma população agrícola de Farroupilha-RS. Foi utilizado um questionário para coletar informações sobre fatores sociodemográficos e de estilo de vida, duração, frequência e tipo de pesticidas utilizados, entre outros. Amostras sanguíneas foram coletadas e analisadas quanto a concentração sérica de 24 pesticidas OC e parâmetros hematológicos. As associações foram exploradas através de regressão linear, controlando por confundidores. O uso cumulativo de classes químicas diferentes de organofosforados e ditiocarbamatos associou-se com diminuição do número de linfócitos enquanto indivíduos que tiveram suas coletas sanguíneas realizadas na estação de maior uso de agrotóxicos tinham contagem de eritrócitos e hemoglobina maiores. Níveis séricos de diversos pesticidas organoclorados foram associados com contagens mais baixas de células brancas do sangue, particularmente eosinófilos. Embora as associações com o uso de agrotóxicos tenham sido, em geral, nulas, os resultados podem sugerir que os pesticidas OCs poderiam levar a alterações hematológicas entre os trabalhadores agrícolas.


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Adulto Jovem , Praguicidas/sangue , Exposição Ocupacional/efeitos adversos , Doenças dos Trabalhadores Agrícolas/epidemiologia , Hidrocarbonetos Clorados/sangue , Praguicidas/toxicidade , Contagem de Células Sanguíneas , Brasil/epidemiologia , Estudos Transversais , Doenças dos Trabalhadores Agrícolas/sangue , Fazendas , Hidrocarbonetos Clorados/toxicidade , Pessoa de Meia-Idade
2.
International Journal of Environmental Research. 2013; 7 (1): 219-224
em Inglês | IMEMR | ID: emr-130248

RESUMO

Zebra fish were exposed to environmentally relevant concentration of pesticides and metals for a period of 14 days. The individual and the combined toxicity of pesticides and metals were studied. Damage caused to the DNA and induction of mutation in the GADD45beta gene was investigated in this study. The present investigation revealed that exposure of zebra fish to pesticides and metals induced DNA damage and also mutation in the GADD45beta gene. The pesticides treated group [III] showed significantly higher damage followed by metals treated group [II]. The DNA damage was comparatively less in the pesticides and metals exposed group [IV]. GADD45beta gene which is considered to be one of the most important gene involved in G phase arrest, has been found to be mutated in zebra fish when exposed to metals and pesticides. The comparison of amplified gene sequence of GADD45beta gene with the sequence of the zebra fish retrieved from the NCBI confirmed the mutation in the gene sequence of zebra fish treated with pesticides and metals. The induction of DNA damage in fish due to contaminants may lead to mutations, which contribute towards the multistage carcinogenesis process


Assuntos
Animais , Peixe-Zebra , Dano ao DNA , Mutação/genética , Hidrocarbonetos Clorados/toxicidade , Praguicidas/toxicidade , Metais Pesados/toxicidade , Peptídeos e Proteínas de Sinalização Intracelular , Carcinogênese
3.
Ciênc. Saúde Colet. (Impr.) ; 15(supl.1): 1169-1174, jun. 2010. tab
Artigo em Espanhol | LILACS | ID: lil-555648

RESUMO

Los productos en desarrollo y los niños son particularmente vulnerables a los tóxicos ambientales. Nuestro objetivo es determinar los niveles de plaguicidas organoclorados (HCB, ß-HCH, pp'DDT, op'DDT y pp'DDE) en lípidos séricos de madres de niños con criptorquidia y comparar los niveles con un grupo control de madres de niños con testículos descendidos. El grupo de los casos fue constituido por recién nacidos con diagnóstico de criptorquidia (n=41). El grupo control (n=41) se conformó por niños con testículos descendidos. A las madres de ambos grupos se les determinaron los niveles de plaguicidas organoclorados. La criptorquidia fue diagnosticada al nacimiento por neonatólogo. Residuos de plaguicidas organoclorados fueron encontrados en lípidos séricos de ambos grupos. Los niveles de la mediana (mgkg-1 en base lipídica) fueron mayores para los metabolitos pp'DDT (0.464 vs. 0.269) y ß-HCH (0.263 vs. 0.192) en el grupo con criptorquidia comparado con el grupo control. (p<0.01). Los niveles de los metabolitos pp'DDT y ß-HCH son mayores entre las madres de los recién nacidos con criptorquidia. Es posible que sustancias con efectos antiandrogénicos puedan producir disrupción endocrina y criptorquidia durante el desarrollo fetal.


Fetuses and children are more susceptible to the effects of environmental toxins. The objective of this article is to determine the levels of organochlorine pesticides (HCB, ß-HCH, pp'DDT, op'DDT and pp'DDE) in the serum lipids of mothers of newborns with cryptorchidism and compare the levels to a control group of mothers of newborns with descended testicles. The cases were composed of newborns with cryptorchidism (n=41), and the controls (n=41) newborns with descended testicles. Blood samples from both groups of mothers were used to determine the organochlorine pesticide levels. Cryptorchidism was diagnosed at birth by a neonatologist. The results showed that the organochlorine pesticide residues were found in the serum lipids of both groups of mothers. The median serum lipid levels (mgkg-1 lipid-based) were statistically higher for the metabolites pp'DDT (0.464 vs. 0.269) and ß-HCH (0.263 vs. 0.192) in the cryptorchidism group compared to the control group (p<0.01). It could be concluded that the levels of the metabolites pp'DDT and ß-HCH are higher among mothers of newborns with cryptorchidism. It is possible that substances with anti-androgenic effects could produce endocrine disruption, such as cryptorchidism, during fetal development.


Assuntos
Feminino , Humanos , Recém-Nascido , Masculino , Criptorquidismo/induzido quimicamente , Hidrocarbonetos Clorados/toxicidade , Exposição Materna/efeitos adversos , Praguicidas/toxicidade , Criptorquidismo/epidemiologia , Hidrocarbonetos Clorados/sangue
4.
Cad. saúde pública ; 24(4): 755-766, abr. 2008. ilus, tab
Artigo em Inglês | LILACS | ID: lil-479690

RESUMO

This article presents the results of a heath risk assessment in Cidade dos Meninos, an area contaminated with organochlorine pesticide residues located in the county (municipality) of Duque de Caxias, Rio de Janeiro State, Brazil. The Agency for Toxic Substances and Disease Registry (ATSDR) risk assessment methodology was applied. The following organochlorine compounds exceeded the established limits and were considered target pollutants: HCH and its isomers (in eggs, milk, and soil); DDT and its metabolites; trichlorobenzenes; trichlorophenols; dioxins and furans (eggs and soil). For all the substances studied (with the exception of trichlorophenols), the estimated doses exceeded the minimum risk levels for chronically exposed children and adults. According to the ATSDR classification, the area was considered an "urgent public health hazard" because of its high and serious exposure to substances that are dangerous to human health.


Cidade dos Meninos é uma área localizada no Município de Duque de Caxias, Rio de Janeiro, Brasil, onde ocorreu contaminação ambiental por deposição de pesticidas organoclorados. Este artigo apresenta os resultados de um estudo de avaliação de risco para a saúde da população residente, utilizando-se a metodologia de avaliação de risco à saúde da Agency for Toxic Substances and Disease Registry. Os seguintes compostos organoclorados superaram as normas estabelecidas e foram considerados contaminantes de interesse: hexaclorociclohexano (HCH) e seus isômeros (ovo, leite, solo); tricloro-bis-(clorofenil)-etano (DDT) e seus metabólitos (ovo, leite, solo); triclorobenzenos (solo); triclorofenóis (solo); dioxinas e furanos (ovo, solo). Para todos os compostos estudados, exceto triclorofenóis, na situação de exposição crônica, as doses estimadas estavam acima dos níveis mínimos de risco à saúde, para crianças e adultos. A área foi classificada como de perigo urgente para a saúde pública por exposição de alta intensidade e grave a substâncias nocivas à saúde humana. Os autores observam que a realização de estudos de avaliação de risco para a saúde humana é uma importante ferramenta para a tomada de decisões para ações de saúde pública.


Assuntos
Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Carcinógenos Ambientais/efeitos adversos , Exposição Ambiental/efeitos adversos , Contaminação de Alimentos/análise , Hidrocarbonetos Clorados/toxicidade , Resíduos de Praguicidas/toxicidade , Solo/análise , Brasil , Carcinógenos Ambientais/análise , Exposição Ambiental/análise , Hidrocarbonetos Clorados/análise , Resíduos de Praguicidas/análise , Medição de Risco
5.
Alexandria Journal of Veterinary Sciences [AJVS]. 2008; 27 (1): 9-17
em Inglês | IMEMR | ID: emr-99691

RESUMO

One hundred and fifty random samples of local meat and fat of beef, buffaloe and mutton carcasses [50 samples of each] were examined for detection of pesticide residues qualitatively and quantitatively by using thin layer chromatography. Organochlorine pesticide residues were detected in meat and fat of examined carcasses with various levels but organophosphate pesticide residue could not be detected in any sample. The pesticide residues in examined samples were compared with the maximum residual levels of pesticide residues


Assuntos
Animais , Resíduos de Praguicidas/toxicidade , Gorduras/análise , Cromatografia/métodos , Hidrocarbonetos Clorados/toxicidade , População Rural
6.
PJMR-Pakistan Journal of Medical Research. 1989; 28 (2): 106-109
em Inglês | IMEMR | ID: emr-95149

RESUMO

As a consequence of industrialization, plant- and food protection an increasing number of chemicals has been developed and applied during the last 50 years. One group of chemicals produced as insecticides are the chlorinated hydrocarbon-derivates [the most well known is DDT]. As such substances are exported from developed [where their use is widely prohibited] to-or produced in-developing countries [where low standards of education in rural population increase the risks of unprotected exposition it seemed worth while to look at their residues in human organism there. We analysed fat and blood of 25 probands from Quetta/Pakistan who underwent surgical operations and found for chemicals of the DDE- and HCH-group much higher levels than those reported from W-Germany. An interesting point is that HCB could not be detected in any of the samples. This is contradictory to common assumption HCB would be spread worldwide


Assuntos
Humanos , Hidrocarbonetos Clorados/toxicidade , Poluição Ambiental
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